Buffalo Homes with Business Opportunity Style

Welcome to Buffalo County, Wisconsin—a hidden gem nestled in the heart of the Driftless Region, where rolling hills, pristine rivers, and a vibrant community come together to create an idyllic lifestyle. Known for its breathtaking natural beauty and rich agricultural heritage, Buffalo County offers a unique blend of rural charm and modern conveniences. Whether you're an outdoor enthusiast, a history buff, or simply seeking a peaceful retreat, this county has something for everyone.

One of the most exciting opportunities in Buffalo County lies in the realm of real estate—specifically, homes with business opportunities. Imagine living in a picturesque setting while also running your own business right from your doorstep! These properties provide the perfect canvas for entrepreneurs looking to start a bed and breakfast, art studio, or even a small farm-to-table restaurant. With ample land, stunning views, and a welcoming community, your business can thrive in this supportive environment.

Buffalo County is conveniently located near major highways, making it easily accessible for both residents and visitors. The charming towns of Alma, Mondovi, and Durand are filled with local shops, restaurants, and cultural attractions, ensuring that you’re never far from the action. Plus, with a strong sense of community and numerous local events, you’ll quickly feel at home.

Investing in a home with a business opportunity in Buffalo County not only allows you to enjoy the tranquil lifestyle but also opens doors to exciting entrepreneurial ventures. Embrace the chance to live, work, and thrive in one of Wisconsin's most beautiful counties!

Newest Buffalo Homes with Business Opportunity Style

$219,000

2 Beds ⋅ 2 Baths ⋅ 7063623 MLS

Opportunity awaits in the heart of downtown Nelson. This mixed use property offers a versatile main level commercial space, a spacious upper level apartment, and extensive lower level storage. Positioned along a well traveled downtown corridor that has previously reported traffic counts of approximately 15,000 vehicles per day, the storefront provides excellent visibility for retail, office, service based businesses, or a variety of entrepreneurial ventures. The property also includes ownership of both driveways and an oversized two car garage, offering valuable parking and access flexibility. Upstairs, the residential unit offers an ideal setup for an owner operator looking to live on site, provide employee housing, or generate additional rental income. The apartment features large living spaces filled with natural light, two bedrooms, a full kitchen, two bathrooms, newer windows installed in 2020, and additional flex space that could serve as storage, office space, or a sunroom. Original woodwork adds character throughout, while the layout offers opportunities to update and tailor the space to your vision. The lower level provides substantial storage and utility space, adding even more functionality for business operations. A unique opportunity to establish your business while benefiting from additional residential space in a prime downtown Nelson location near the Mississippi River.

S101 S Main Street, Nelson

Listing courtesy of Re/Max Results.

$214,000

7061302 MLS

Exceptional opportunity to own a well maintained mixed-use property in the heart of downtown Alma along Wisconsin’s scenic Great River Road. This versatile building features retail/commercial space on the main level with excellent storefront visibility in a high-traffic downtown location, along with a spacious upper-level apartment offering Mississippi River views. The upper level includes two generous rooms that provide flexibility for bedroom, office, or additional living space needs, along with a bathroom. Whether you're looking to create comfortable living quarters above your business or generate additional rental income, this property offers versatility to fit a variety of needs. Located near Alma’s popular shops, restaurants, marina access, river attractions, Buena Vista Park, and the Great Alma Fishing Float, this property is well positioned for an owner-occupied business, investment opportunity, or live/work lifestyle in one of the Mississippi River’s most charming historic communities.

117 N Main Street, Alma

Listing courtesy of Re/Max Results.

$395,000

7056657 MLS

Rare opportunity to own one of Wisconsin’s most historic and beloved hospitality destinations. Originally known as the Union House and dating back to the pre-Civil War era, the Historic Alma Hotel is recognized as one of the oldest continually operating restaurants in the state. Located along the scenic Great River Road in Alma, this well-established property features a full-service restaurant, bar, outdoor patio, breakfast area, game room, exterior cooler, and additional storage space with a covered lean-to. A commercial food license for catering creates added income potential. The upper-level hotel accommodations include eight guest rooms, with two offering double beds, two offering queen beds, and four offering full-size beds, along with six shared bathrooms and two private bathrooms. Known for its strong regional reputation and loyal customer base, the property draws both locals and visitors traveling through the Mississippi River region year-round. Recent updates include refinished floors (April 2026), an updated electrical panel (2022), and a fully remodeled commercial kitchen with all equipment replaced within the past four years, with all appliances included. A truly unique opportunity to own a thriving business rich in history, character, and lasting community presence.

201 N Main Street, Alma

Listing courtesy of Re/Max Results.

$94,900

1 Baths ⋅ 7052429 MLS

What was once the German American Bank Building with 2 Bank Vaults (Est. 1906) and later Bautch Insurance (Est. 1947) has now been improved and ready for you to establish this building with your Vision, Service or Big Ideal in mind. New Owners have recently replaced all flooring with LVP, have repainted all services, constructed a new interior wall and added new ceiling tiles which will enable the new owner to hit the ground running! This 1,275 sqft single level building includes a large, open front room, a 1/2 bathroom, a 2nd sink and utility area, 2 secure rooms which each housed 2 massive bank vaults, plus 2 additional, fully finished rooms. Forced air/Central A/C for efficient heating and cooling, beautiful new flooring, paint & ceilings make this space perfect for many purposes. Business, retail, or personal living are all options and with an asking price of under $95,000 - we expect that many prospective Buyers will be interested!

117 S Main Street, Alma

Listing courtesy of Jewson Realty.

$250,000

2 Beds ⋅ 1 Baths ⋅ 7038062 MLS

Established business located along the Mississippi River; on the scenic Great River Road, Hwy 35! Excellent visibility and a destination place. Located 1.5 hours to Twin Cities, 10 min. to Winona, Mn., 40 min to La Crosse, Wi., 2.5 hours to Madison, Wi. Historic Golden Frog; Est. 1887-supper club-bar-grill-2 bdrm apartment, outside patio seating. Daily dining/special events & parties the Frog hosts. Remodeled in 2008. Excellent opportunity to run a business that has survived the test of time and enjoy a quiet living in this quaint river town. 2 Bedroom Apartment upstairs, great opportunity to live on site and manager your business. . Pre-approved buyers-no solicitation at business please.

112 N Shore Drive, Fountain City

Listing courtesy of Century 21 Affiliated.

$159,900

7022782 MLS

Overlooking the Mississippi in the picturesque town of Alma, WI awaits an affordable business opportunity! Pier 4 has a great history in the community from locals to tourists. Now for sale ready for your own ideas to flourish. Being right on the "Great River Road" this property sees a lot of traffic and with off street and on street parking there is room for many customers to park close.

600 N Main Street, Alma

Listing courtesy of Jewson Realty.

$739,900

6817837 MLS

Turnkey liquor store on the scenic Mississippi River Road with strong local and tourist traffic from Stockholm, Maiden Rock, Pepin, Nelson and Alma. Includes real estate, fixtures, and full inventory. The nearest competitor is 10 miles away with higher prices, giving this store a clear value advantage while still offering a strong selection. Excellent visibility, camera monitoring, easy parking, and steady year around business from travelers, motorcyclists, fishermen and hunters. A rare opportunity in a charming river town known for its events and consistent visitor flow.

207 N Main Street, Nelson

Listing courtesy of RE/MAX Results.

$580,000

1 Beds ⋅ 1 Baths ⋅ 6709750 MLS

Just outside Fountain City, this unique property offers a rare combination of investment opportunity and lifestyle appeal. Featuring a spacious bar with a large stage and generous serving area, it's ideal for live music, private events, or starting your own venue. Attached is a comfortable 3-bedroom living space, making it perfect for owner-occupancy or rental income. The property includes additional land—perfect for building more rentals or even your dream home with sweeping views of the Mississippi River. Recent updates like a brand-new roof and modernized electrical system make this a move-in-ready opportunity. Enjoy breathtaking panoramic river views and a peaceful setting, all within easy reach of Winona and Trempealeau. Whether you're an investor, entrepreneur, or dreamer, this one checks all the boxes.

W626 Midway Road, Fountain City

Listing courtesy of Coldwell Banker Commercial River Valley.

$695,000

6603102 MLS

This is an amazing opportunity to own a successful business with breathtaking, million-dollar views of the Mississippi River. With 120 feet of leased river frontage and 3 new docks, it's the perfect spot for boaters to stop and enjoy a great meal. All the major updates have been completed, including a new roof, electric service box, newer furnace and AC, and a brand new well scheduled for 2024 — just to name a few. The entire property, inside and out, has been lovingly renovated by the current owner, including the nearly fully remodeled living quarters above the business. You could live upstairs or rent it out for added income potential. The beautifully upgraded interior features custom table tops and an incredible bar top that perfectly complements the unforgettable views.

356 W 16th Street, Buffalo City

Listing courtesy of Keller Williams Premier Realty.

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